TENBORON LTD
Novel boron carriers for Boron Neutron Capture Therapy

NEWS

TENBORON’S LEAD MOLECULE ENTERS CLINICAL STAGE

The Finnish Medicines Agency Fimea has approved Tenboron’s Phase I clinical trial application.
The study will be conducted at the Helsinki University Hospital.
Preparations for study initiation are underway.

BORON NEUTRON CAPTURE THERAPY (BNCT)

BNCT is biochemically targeted radiation therapy. Boron-10 (10B) atoms are selectively delivered to the tumor, followed by irradiation with epithermal neutrons (nth). A nuclear reaction occurs, when a 10B atom captures a neutron. The short range of the reaction products restricts most of the radiation dose to the boron-loaded cells.

NEUTRON CAPTURE REACTION

The stable boron isotope 10B has a large neutron capture radius. Thus 10B is more likely to capture neutrons than many other elements that are present in biological environments (e.g. nitrogen and hydrogen). A fission reaction occurs upon neutron capture, and a lithium ion and an alpha particle are produced. These particles have high kinetic energies, but their range is only about 10 microns. This leads to very efficient cancer cell killing precisely at the site of boron accumulation.
Tenboron Lead molecule

BENEFITS OF BNCT

Potential
Has been in previous studies curative for 15-20% of terminal phase patients, despite using sub-optimal boron carrier
Can be used to treat many kinds of solid tumors that can be boron loaded
Affects healthy tissues less than conventional radiation therapy
Can be used in combination with other treatments

Cost-effective
Low number of treatment sessions
Short hospital period – outpatient in many cases

Can be repeated 

TENBORON’S LEAD BORON CARRIER HAS A HIGH NUMBER OF BORON ATOMS AND AN ANTIBODY TARGETING UNIT THAT DIRECTS THE CARRIER SPECIFICALLY TO CANCEROUS CELLS

Boron molecule

IMPROVING THE BORON CARRIER IS ONE OF THE GREATEST CHALLENGES OF BNCT

  • The boron concentration gradient between tumor and surrounding healthy tissue should be significantly increased
  • The boron concentration in the tumor cells should be significantly increased
  • The targeting of the boron carrier to the tumor cells (carrier cell surface affinity and/or cell internalisation) should be significantly improved
  • The kinetics of the boron carrier should allow for a long time period within the tumor cells 

TENBORON’S LEAD BORON CARRIER IS ADMINISTERED DIRECTLY INTO THE TUMOR, FOLLOWED BY NEUTRON IRRADIATION

Boron Neutron Capture reaction leads to intense local irradiation precisely at the site of boron accumulation, which leads to tumor necrosis

TENBORON LTD.

  • Founded 2010, commenced operation in 2011
  • Inspired by the successful trials conducted at the Helsinki University Central Hospital and the VTT nuclear reactor facility FiR-1
  • Privately held SME, over 500 shareholders
  • Financial support from Business Finland
  • Three boron carriers in development pipeline:
    • Lead molecule is an antibody-boron conjugate
    • Novel formulation for BPA for improved stability
    • A glioma targeting peptide-boron conjugate

PEOPLE AND PARTNER NETWORK

Board and management

Dr. Timo Veromaa,
Chairman

Dr. Anu Muona,
Board Member

Mr. Juhani Saarinen,
Board Member

Dr. Seppo Pakkala,
Board Member and Chief Medical Officer

Mr. Juha Jouhki,
Chief Executive Officer

R&D and project management

Dr. Jari Helin,
Head of CMC

Dr. Jukka Hiltunen,
Project manager

QUALITY ASSURANCE

Ms. Sirkku Holttinen,
Quality Assurance Manager

 

MANUFACTURING

manufacturing

Partners: Biovian Ltd.
and
Medfiles Ltd.

CLINICAL RESEARCH

clinical2

Partner: Optimapharm Ltd.

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