TENBORON – Boron Neutron Capture Therapy

TENBORON LTD

Novel boron carriers for Boron Neutron Capture Therapy

BORON NEUTRON CAPTURE THERAPY (BNCT)

BNCT is biochemically targeted radiation therapy. Boron-10 (10B) atoms are selectively delivered to the tumor, followed by irradiation with epithermal neutrons (nth). A nuclear reaction occurs, when a 10B atom captures a neutron. The short range of the reaction products restricts most of the radiation dose to the boron-loaded cells.

NEUTRON CAPTURE REACTION

The stable boron isotope 10B has a large neutron capture radius. Thus 10B is more likely to capture neutrons than many other elements that are present in biological environments (e.g. nitrogen and hydrogen). A fission reaction occurs upon neutron capture, and a lithium ion and an alpha particle are produced. These particles have high kinetic energies, but their range is only about 10 microns. This leads to very efficient cancer cell killing precisely at the site of boron accumulation.

BENEFITS OF BNCT

Potential
Has been in previous studies curative for 15-20% of terminal phase patients, despite using sub-optimal boron carrier
Can be used to treat many kinds of solid tumors that can be boron loaded
Affects healthy tissues less than conventional radiation therapy
Can be used in combination with other treatments

Cost-effective
Low number of treatment sessions
Short hospital period – outpatient in many cases

Can be repeated

TENBORON’S LEAD BORON CARRIER HAS A HIGH NUMBER OF BORON ATOMS AND AN ANTIBODY TARGETING UNIT THAT DIRECTS THE CARRIER SPECIFICALLY TO CANCEROUS CELLS

IMPROVING THE BORON CARRIER IS ONE OF THE GREATEST CHALLENGES OF BNCT

The boron concentration gradient between tumor and surrounding healthy tissue should be significantly increased
The boron concentration in the tumor cells should be significantly increased
The targeting of the boron carrier to the tumor cells (carrier cell surface affinity and/or cell internalisation) should be significantly improved
The kinetics of the boron carrier should allow for a long time period within the tumor cells

TENBORON’S LEAD BORON CARRIER IS ADMINISTERED DIRECTLY INTO THE TUMOR, FOLLOWED BY NEUTRON IRRADIATION

Boron Neutron Capture reaction leads to intense local irradiation precisely at the site of boron accumulation, which leads to tumor necrosis

TENBORON LTD.

Founded 2010, commenced operation in 2011
Inspired by the successful trials conducted at the Helsinki University Central Hospital and the VTT nuclear reactor facility FiR-1
Privately held SME
Financial support from Business Finland

ACHIEVEMENTS TO DATE

A number of different molecular designs has been evaluated, and the most promising one selected
Efficacy tests in small animals have been carried out
Results are far superior to anything achieved with current boron carriers
A robust synthesis route has been designed
A contract manufacturer has been selected for the investigational product, and successful pre-GMP production test runs have been performed
Preclinical toxicology studies have been carried out successfully
In addition to the lead molecule, two other boron carriers are in early preclinical development phase